Richard A. Lawhern, Ph.D., writing on the Global Summit for Diagnostic Alternatives (DxSummit.org) suggests:
"The whole notion of “brain circuit” is meaningless word noise. What we have instead is a distributed self-adaptive synapse network operating in a massively parallel biological processor whose electrical architecture is mediated by multiple competing external inputs. Science doesn’t presently know how to model such a combination — and it quite possibly never will. We can’t model the machine from inside it."
Note: Dr. Lawhern's Ph.D. is in Engineering Systems. His career experience includes the assessment of advanced technologies in human factors, perception, and decisionmaking.